金紅林 博士、教授、博导

教育經曆：

2007/09-2012/06，華中科技大學，生物化學與分子生物學，博士

2005/09-2007/06，華中科技大學，生物化工，碩士

2001/09-2005/06，湖北工業大學，生物工程，本科

工作經曆與任職：

2021/04-至今，華中農業大學，yabo与健康學院，教授

2014/07-2021/04，華中科技大學，武漢協和醫院腫瘤中心，講師/副研究員/研究員

2012/04-2014/06，華中科技大學，武漢光電國家實驗室，博士後

2008/05-2011/01，多倫多大學/安大略癌症研究院，Medical Biophysics，訪問學者

研究方向：

腫瘤免疫治療新技術、新靶點，以及相關免疫機制研究，注重學科交叉融合和臨床轉化。

1、免疫細胞調控/重塑新靶點和新機制；

2、放射衍生物和腫瘤免疫治療：通過研究經典的放射生物學效應，對放療産物進行鑒定分析，一方面探索放療免疫增效新機制，另一方面建立系列“間接放療新技術”；

3、通過設計系列抗腫瘤載體平台策略，克服腫瘤免疫抑制性微環境，提高T細胞在腫瘤微環境中的活性，構建個體化腫瘤疫苗。

代表性論文：

1. Jingshu Meng^#, Xiao Yang^#, Jing Huang^#, Zhan Tuo, Yan Hu, Zhiyun Liao, Yu Tian, Suke Deng, Yue Deng, Zhiyuan Zhou, Jonathan F. Lovell, Honglin Jin*, Yang Liu* and Kunyu Yang*. Ferroptosis-enhanced immunotherapy with an injectable dextran-chitosan hydrogel for for the treatment of malignant ascites in hepatocellular carcinoma. Advanced Science. 2023.

2. Lisen Lu^#, Huaduan Zi^#, Jie Zhou^#, Jing Huang, Zihan Deng, Zijian Tang, Li Li, Xiujuan Shi, Pui-Chi Lo, Jonathan F. Lovell, Deqiang Deng*, Chao Wan*, Honglin Jin*. Engineered microparticles for treatment of murine brain metastasis by reprograming tumor microenvironment and inhibiting MAPK pathway. Advanced Science. 2023, 2206212.

3. Xiujuan Shi^#, Jun Zhang^#, Junkai Liu, Xueqian Zhao, Haoran Wang, Peifa Wei, Xiaodong Zhang, Xin-Long Ni, Herman H.-Y. Sung, Ian D. Williams, Wai Kit Ng, Kam Sing Wong, Jacky W. Y. Lam, Lin Wang*, Honglin Jin*, Ben Zhong Tang*. Hierarchical Supramolecular Self-assembly: Fabrication and Visualization of Multiblock Microstructures. Angew. Chem. Int. Ed. 2022, e202211298.

4. Zhiyun Liao^#, Jing Huang^#, Pui-Chi Lo, Jonathan F. Lovell, Honglin Jin*, Kunyu Yang*. Self-adjuvanting Cancer Nanovaccines. Journal of Nanobiotechnology. 2022. 20 (1), 1-20.

5. Danyi Zai^#, Jing Huang^#, Yan Hu^#, Chao Wan, Yajie Sun, Jingshu Meng, Huaduan Zi, Lisen Lu, Qianyuan He, Yu Hu, Honglin Jin*, Kunyu Yang*. Ionizing radiation-induced tumor cell-derived microparticles prevent lung metastasis by remodeling the pulmonary microenvironment. International Journal of Radiation Oncology Biology Physics. 2022. 114 (3), 502-515.

6. Yan Hu^#, Yajie Sun^#, Chao Wan, Xiaomeng Dai, Shuhui Wu, Pui-Chi Lo, Jing Huang, Jonathan F. Lovell, Honglin Jin*, Kunyu Yang*. Microparticles: biogenesis, characteristics and intervention therapy for cancers in preclinical and clinical research. Journal of Nanobiotechnology. 2022. 20(1), 189.

7. Zhan Tuo^#, Qianyuan He^#, Zhanjie Zhang^#, Haojie Liu, Jie Zhou, Yan Hu, Yajie Sun, Chao Wan, Zushun Xu, Jonathan F. Lovell, Honglin Jin*, Kunyu Yang*. Irradiation conditioning of adjuvanted, autologous cancer cell membrane nanoparticle vaccines. Chemical Engineering Journal. 2022. 433: 134437.

8. Yuhan Zhou^#, Ting Ye^#, Chengzhi Ye^#, Chao Wan, Siyue Yuan, Yushuai Liu, Tianyu Li, Fagang Jiang, Jonathan F. Lovell, Honglin Jin*, Jing Chen*. Secretions from hypochlorous acid-treated tumor cells delivered in a melittin hydrogel potentiate cancer immunotherapy. Bioactive Materials. 2022. 9, 541-553.

9. Chao Wan^#, Yajie Sun^#, Yan Hu^#, Jing Huang^#, Lisen Lu, Jingshu Meng, Yanan Gao, Huaduan Zi, Qianyuan He, Jonathan F. Lovell, Kunyu Yang*, Honglin Jin*. Radiated tumor cell secretions loaded peptide hydrogel for immunotherapy to advanced cancer. Nano Today. 2021. 41, 101323.

10. Yushuai Liu^#, Yuanyuan Geng^#, Beilei Yue, Pui-Chi Lo, Jing Huang*, Honglin Jin*. Injectable Hydrogel as A Unique Platform for Antitumor Therapy Targeting Immunosuppressive Tumor Microenvironment. Frontiers in Immunology. 2021. 12, 832942.

11. Jingshu Meng^#, Yan Li^#, Chao Wan^#, Yajie Sun, Xiaomeng Dai, Jing Huang, Yan Hu, Yanan Gao, Jonathan F. Lovell, Gang Wu, Honglin Jin*, Kunyu Yang*. Targeted senescence-like cancer-associated fibroblasts increases non-small cell lung cancer radiosensitivity and ameliorates radiation-induced pulmonary fibrosis. JCI Insight. 2021. 6(23): e146334.

12. Yajie Sun^#, Yan Hu^#, Chao Wan, Jonathan F. Lovell, Honglin Jin*, Kunyu Yang*. Local biomaterials-assisted immunotherapy for effusions in the pleural and peritoneal cavities caused by malignancies. Biomaterials Science. 2021. 9, 6381-6390.

13. Lisen Lu^#, Yajie Sun^#, Chao Wan, Yan Hu, Pui-Chi Lo, Kunyu Yang*, Honglin Jin*. Role of intravital imaging in nanomedicine-assisted anti-cancer therapy. Current Opinion in Biotechnology. 2021. 69. 153-161.

14. Jie Zhou^#, Chao Wan^#, Jing Cheng, Hao Huang*, Jonathan F. Lovell, Honglin Jin*. Delivery strategies for melittin-based cancer therapy. ACS Applied Materials & Interfaces. 2021. 13, 15, 17158–17173.

15. Yanan Gao^#, You Qin^#, Chao Wan, Yajie Sun, Jingshu Meng, Yan Hu, Jing Huang, Honglin Jin*, Kunyu Yang*. Small extracellular vesicles: a novel avenue for cancer management. Frontiers in Oncology. 2021. 11 : 441

16. Yajie Sun, Xiangru Feng, Chao Wan, Jonathan F. Lovell, Honglin Jin*, Jianxun Ding*. Role of nanoparticle-mediated immunogenic cell death in cancer immunotherapy. Asian Journal of Pharmaceutical Sciences. 2021. 6.12 : 129-132.

17. Chao Wan^#, Yajie Sun^#, Yu Tian^#, Lisen Lu, Xiaomeng Dai, Jingshu Meng, Jing Huang, Qianyuan He, LingLing Zhang, Jonathan F. Lovell, Gang Wu, Honglin Jin*, Kunyu Yang*. Irradiated tumor cell-derived microparticles mediate tumor eradication via cell killing and immune reprogramming. Science Advances. 2020. 6 : eaay9789.

18. Xiaomeng Dai^#, Lisen Lu^#, Suke Deng, Jingshu Meng, Chao Wan, Jing Huang, Yajie Sun, Yan Hu, Bian Wu, Gang Wu, Jonathan F. Lovell, Honglin Jin*, Kunyu Yang*. USP7 targeting modulates antitumor immune response by reprogramming tumor-associated macrophages in lung cancer. Theranostics. 2020. 10(20):9332-9347.

19. Xiaomeng Dai^#, Jingshu Meng^#, Suke Deng^#, Lingling Zhang, Chao Wan, Lisen Lu, Jing Huang, Yan Hu, Zhanjie Zhang, Jonathan F. Lovell, Gang Wu, Kunyu Yang*, Honglin Jin*. Targeting CAMKII to reprogram tumor-associated macrophages and inhibit tumor cells for cancer immunotherapy with an injectable hybrid peptide hydrogel. Theranostics. 2020. 10(7): 3049-3063.  

20. Qianyuan He^#, Zhanjie Zhang^#, Haojie Liu, Zhan Tuo, Jie Zhou, Yan Hu, Yajie Sun, Chao Wan，Zushun Xu, Jonathan F. Lovell, Desheng Hu*, Kunyu Yang*, Honglin Jin*. Relieving immunosuppression during long-term anti-angiogenesis therapy using photodynamic therapy and oxygen delivery. Nanoscale. 2020. 12, 14788-14800.

21. Boyang Sun^#, Jing Huang^#, Moustafa T. Mabrouk, Yumiao Zhang, Honglin Jin*, Jonathan F Lovell*. A surfactant-stripped cabazitaxel micelle formulation optimized with accelerated storage stability. Pharmaceutical Development and Technology. 2020. 25.10: 1281-1288.

22. Haojie Liu^#, Yan Hu^#, Yajie Sun^#, Chao Wan, Zhanjie Zhang, Xiaomeng Dai, Zihan Lin, Qianyuan He, Zhe Yang, Piao Huang, Yuxuan Xiong, Jinguo Cao, Xu Chen, Qi Chen, Jonathan F. Lovell, Zushun Xu*, Honglin Jin* and Kunyu Yang*. Co-delivery of bee venom melittin and a photosensitizer with an organic–inorganic hybrid nanocarrier for photodynamic therapy and immunotherapy. ACS Nano. 2019. 13(11), 12638-12652.

23. Dyego Miranda^#, Chao Wan^#, Hailey I Kilian, Moustafa T. Mabrouk, Yuhan Zhou, Honglin Jin*, Jonathan F Lovell*. Indocyanine green binds to DOTAP liposomes for enhanced optical properties and tumor photoablation. Biomater. Sci. 2019, 7, 3158-3164.  

24. Honglin Jin^#, Chao Wan^#, Zhenwei Zou^#, Guifang Zhao, LingLing Zhang, Yuanyuan Geng, Tong Chen, Ai Huang, Fagang Jiang, Jue-Ping Feng, Jonathan F. Lovell, Jing Chen*, Gang Wu*, and Kunyu Yang*. Tumor Ablation and Therapeutic Immunity Induction by an Injectable Peptide Hydrogel. ACS Nano. 2018, 12 (4), 3295–3310.

25. Yanwu Chu, Feng Chen, Yun Tang, Tong Chen, Yunxin Yu, Honglin Jin*, Lianbo Guo*, Yongfeng Lu, and Xiaoyan Zeng. Diagnosis of nasopharyngeal carcinoma from serum samples using hyperspectral imaging combined with a chemometric method. Optics Express. 2018. 26 (22), 28661-28671.

26. Yanwu Chu^#, Tong Chen^#, Feng Chen, shisong Tang, Yun Tang, Honglin Jin*, Lianbo Guo*, YongFeng Lu, and Xiaoyan Zeng. Discrimination of nasopharyngeal carcinoma serum using laser-induced breakdown spectroscopy combined with an extreme learning machine and random forest method. Journal of Analytical Atomic Spectrometry. 2018. 33, 2083-2088.

27. Yibiao Zou^#, Honglin Jin^#, Fei Sun, Xiaomeng Dai, Zushun Xu, Sheng-li Yang, Guangfu Liao. Design and Synthesis of Lead Sulfide-Based Nanotheranostic Agent for Computer Tomography/Magnetic Resonance Dual-Mode Bioimaging Guided Photothermal Therapy. ACS Appl. Nano Mater. 2018. 1 (5), 2294–2305.

28. Honglin Jin^#, Guifang Zhao^#, Jianli Hu^#, Quanguang Ren, Kui Yang, Chao Wan, Ai Huang, Pindong Li, Jue-Ping Feng, Jing Chen*, and Zhenwei Zou*. Melittin-Containing Hybrid Peptide Hydrogels for Enhanced Photothermal Therapy of Glioblastoma. ACS Applied Materials & Interfaces, 2017. 9(31): 25755-25766.

29. Honglin Jin, Yuan Qian, Yanfeng Dai, Sha Qiao, Yuan Qian, Chuan Huang, Jing Chen*, Zhihong Zhang*. Magnetic Enrichment of Dendritic Cell Vaccine in Lymph Node with Fluorescent-Magnetic Nanoparticles Enhanced Cancer Immunotherapy. Theranostics, 2016. 6(11): 2000-2014.

30. Yuan Qian^#, Honglin Jin^#, Sha Qiao, Yanfeng Dai, Chuan Huang, Lisen Lu, Qingming Luo*, Zhihong Zhang*. Targeting dendritic cells in lymph node with an antigen peptide-based nanovaccine for cancer immunotherapy. Biomaterials. 2016. 98: 171-83.

基金項目：

1. 國家自然科學基金面上項目、82272851、2023/01-2026/12 、主持。

2. 國家自然科學優秀青年基金、82022040、2021/01-2023/12、主持。

3. 華中農業大學yabo与健康學院創新團隊、2022/06-2024/04、主持。

4. 華中農業大學高層次人才啓動經費、2021/04-2026/04、主持。

5. 湖北省重点研发计划第二批（国际合作领域）、2020BHB021、主持。

6. 国家自然科学基金面上项目、81874233、2019/01-2022/12、主持。

7. 国家自然科学基金青年项目、81503026、2016/01-2018/12、主持。

8. 湖北省自然科学基金面上项目、2019CFB465、2019/01-2020/12、主持。

9. 吴阶平医学基金会专项基金、320.6750.18385、2018/06-2021/05、主持。

10. 2017年华中科技大学“学术新人”、人才启动经费、主持。

11. 武汉协和医院院内基金、2016.03-2018.03、主持。

12. 华中科技大学青年教师基金、2015QN1、2015/01-2016/12、主持。

13. 生物靶向治疗研究湖北省重点实验室开放基金、2015-2017、主持。

14. 中国博士后科学基金特别资助、2013T60721、2013/06-2014/06、主持。

15. 中国博士后科学基金面上资助、2012M521430、2012/06-2014/04、主持。

授權專利：

1. 一种抗肿瘤疫苗复合物及其制剂、制法及应用：金紅林，楊坤禹，萬超，孫亞潔，張玲玲。專利號ZL201910031298.5。

2. 一種促進樹突細胞攝取抗原肽的多肽、促進樹突細胞攝取抗原肽的納米顆粒及其應用：駱清銘、張智紅、金紅林、錢源。專利號ZL201410166872.5。

3. 一種同時實現促進樹突細胞遷移至淋巴結和多模式成像的方法：張智紅、金紅林、張宇、戴豔鋒。專利號ZL201510788151.2。

4. 一種可自組裝成水凝膠的腫瘤殺傷性多肽及其應用：鄒枕玮，金紅林，陳靜，伍鋼，楊坤禹，胡建莉，彭綱，馮覺平，李品東，趙桂芳。專利號ZL201611105009.4。

學術兼職：

擔任亞太醫學生物免疫學會腫瘤學分會首屆委員會委員，湖北省醫學生物免疫學學會老年病專委會副主任委員，湖北省醫學生物免疫學學會轉化醫學專委會常務委員，以及湖北省臨床腫瘤學會第一屆腫瘤微環境專家委員會常務委員。基金委人才項目函評專家和湖北省重點項目評審專家，Journal of Nanobiotechnology和Bioengineering客座編輯，Chinese Chemical Letters (CCL) 、Frontiers in Bioengineering and Biotechnology和Bioengineering等期刊编委。Nature Communications、Nano today、Advanced Functional Materials、ACS nano、Biomaterials、Theranostics、Cancer Communications、Chinese Chemical Letters、Frontiers in Oncology、Bioconjugate Chemistry、Frontiers in Bioengineering and Biotechnology和Asian Journal of Pharmaceutical Sciences等30余种期刊审稿人。

主講課程：

藥理學（本科）

聯系方式（郵箱）：jin@mail.jinxiniu168.com