李瓅 (Li Li，PhD, Professor) 博士、教授、博士生導師
Education (教育經曆)：
2008-2015, Ph.D. (醫學博士), Princess Margaret Cancer Centre, and Department of Medical Biophysics, Faculty of Medicine, University of Toronto (2020泰晤士高等教育世界大學排名#18).
2004-2008, Honours Bachelor of Science Degree (本科，榮譽理科學士), Immunology Specialist Program, Department of Immunology, Faculty of Medicine, University of Toronto.
2000-2004, Ontario Secondary School Diploma, Ontario Scholar, Canadian International School (Singapore).
Professional Experiences (科研工作經曆)：
2021-present，Professor, College of Biomedicine and Health & College of Life Science and Technology, Huazhong Agricultural University (華中農業大學, yabo与健康學院, 生命科學技術學院，教授).
2019-2020，Research Fellow, Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, University of Toronto (加拿大多倫多大學兒童醫院腦腫瘤研究中心研究員).
2015-2018，Postdoctoral Fellow, Structural Genomics Consortium and University of Toronto（加拿大多倫多大學結構基因組學研究所博士後）.
2007 Summer, Research Assistant, Immunology Specialist Summer Research Program, Department of Immunology, University of Toronto.
2004-2006 Summers, Research Assistant, Laboratory of Molecular Genetics, Huazhong Normal University.
Research Interests (研究方向)：
通過跨學科的多種實驗策略研究癌症起源與致癌機理，免疫學, 遺傳學，DNA損傷修複landscape，免疫治療及新型抗癌療法，蛋白質學以及有關對人類生理與疾病具有重要作用的生物分子非共價相互作用的機理等。
Selected Publications（代表論文）:
Zhang H #, Dong C#, Li L#, Wasney GA, Min J. Structural insights into the modulatory role of the accessory protein WYL1 in the Type VI-D CRISPR-Cas system. Nucleic Acids Research, 2019, 47: 5420–5428. (#co-first author, equal contributions)
Li L#, Guturi KKN#, Gautreau B, Patel PS, Saad A, Morii M, Mateo F, Palomero L, Barbour H, Gomez A, Ng D, Kotlyar M, Pastrello C, Jackson HW, Khokha R, Jurisica I, Affar EB, Raught B, Sanchez O, Alaoui-Jamali M, Pujana MA, Hakem A, Hakem R. Ubiquitin ligase RNF8 suppresses Notch signaling to regulate mammary development and tumorigenesis. Journal of Clinical Investigation, 2018, 128: 4525–4542. (#equal contributions)
Dong C#, Zhang H#, Li L#, Tempel W, Loppnau P, Min J. Molecular basis of GID4-mediated recognition of degrons for the Pro/N-end rule pathway. Nature Chemical Biology (2018) 14: 466–473. (#co-first author, equal contributions)
Ghamrasni SE, Cardoso R, Li L, Guturi KKN, Bjerregaard VA, Liu Y, Venkatesan S, Hande MP, Henderson JT, Sanchez O, Hickson ID, Hakem A, Hakem R. Rad54 and Mus81 cooperation promotes DNA damage repair and restrains chromosome missegregation. Oncogene, 2016, 35: 4836–4845.
Halaby M, Hakem A, Li L, Ghamrasni SE, Venkatesan S, Hande MP, Sanchez O, Hakem R. Synergistic interaction of Rnf8 and p53 in the protection against genomic instability and tumorigenesis. PLoS Genetics, 2013, 9(1):e1003259.
Li L, Halaby M, Hakem A, Cardoso R, Ghamrasni SE, Harding S, Chan N, Bristow R, Sanchez O, Durocher D, Hakem R. Rnf8 deficiency impairs class switch recombination, spermatogenesis, and genomic integrity and predisposes for cancer. Journal of Experimental Medicine, 2010, 207: 983–997.
Funding & Awards（資助與獎項）:
1. 華中農業大學高层次引进人才启动经费
2. Restracomp Fellowship 2019-2020, Canada.
3. University of Toronto Doctoral Completion Award 2013-2014, Canada.
4. 2 MBP UTF Excellence Awards 2011-2013, Canada.
5. Keystone Symposium Scholarship 2011, the USA.
6. Ontario Graduate Scholarship 2011-2012, Canada.
7. Chinese Government Award for Outstanding Self-financed Students Abroad 2010 (中國“國家優秀自費留學生獎學金”), China.
8. Full Scholarship for PhD program in Biomedical Sciences at the Albert Einstein College of Medicine, 2008, New York, the USA. (Declined; 2007 GRE scores above 90 percentiles).
9. 2 Shou-Yun Pang Scholarships 2006-2008, the University of Toronto, Canada.
10. New College Student Council In-Course OSOTF Scholarship 2005-2006, the University of Toronto, Canada.
11. Canadian Open Mathematics Challenge Honour Roll (international student category), 2002，the Canadian Mathematical Society, Canada.
Courses（講授課程）:
Immunobiology (免疫生物學等, 全英文教學)
Research Opportunities (實驗室人員招聘信息)：
The lab currently has opportunities opening for graduate students, postdoctoral trainees, bioinformaticians，technicians and research assistants. All interested people are encouraged to contact me by email with a detailed CV, plus any other related materials (Any relevant skill including programming or academic qualification is an asset, and please provide a brief description).本实验室现招募博士和硕士研究生、博士后、科研助理及volunteer实习生等科研人员。本实验室对学生采取小而精的双语或全英语培养模式，鼓励学生pursue academic excellence, 开展自己感兴趣的科學研究成长为independent scientists;博士后根据积累的科研经验，按年薪制加绩效，包括lab和学校提供的薪酬及各种福利待遇等，请先email detailed Curriculum Vitae, 然后面议。本招聘长期有效。 欢迎大家联系我(Email: lili.johnny@mail.jinxiniu168.com)，加盟实验室或合作研究，共同发展科研事业, 探索宇宙奥秘！
