張強 博士、副教授、碩士生導師

ZhangQ_0401@mail.jinxiniu168.com

研究方向

傳染病致病與免疫機制；腸道微生物穩態與人體健康

教育經曆

2005.9-2009.6 山东农业大学，动物医学，学士

2009.9-2015.6 华中农业大学，预防兽医学，博士

工作經曆

2015.7-2020.9 华中农业大学，生命科学技术学院，博士后

2020.9至今 华中农业大学，副教授

發表論文

1. Zhang Q, Hu J, Feng J, Hu X, Wang T, Gong W, Huang K, Guo Y, Zou Z, Lin X, Zhou R, Yuan Y, Zhang A, Wei H, Cao G, Liu C*, Chen L*, Jin M*, Influenza infection elicits an expansion of gut population of endogenous Bifidobacterium animalis which protects mice against infection. Genome Biol. 2020, 21(1):99.

2. Zhang Q#, Zhang H#, Gao J#, Huang K, Yang Y, Hui X, He X, Li C, Gong W, Zhang Y, Zhao Y, Peng C, Gao X, Chen H, Zou Z*, Shi Z*, Jin M*. A serological survey of SARS-CoV-2 in cat in Wuhan. Emerg Microbes Infect. 2020, 9(1):2013-2019.

3. Zhang Q#,  Huang J#, Yu J,  Xu Z,  Liu L, Song Y, Sun X, Zhang A* and Jin M*, HP1330 Contributes to Streptococcus suis Virulence by Inducing TLR2- and ERK1/2-Dependent Pro-in?ammatory Responses and Influencing In Vivo S. suis Loads, Front Immunol. 2017, 8:869.

4. Huang K#, Zhang Q#, Song Y, Zhang Z, Zhang A, Xiao J, Jin M*, Characterization of Spectinomycin Resistancein Streptococcus suis Leads to Two Novel Insights into Drug Resistance Formation and Dissemination Mechanism, Antimicrob Agents Chemother. 2016, 7.25, (60): 6390~6392. (共同第一作者)

5. Zhang Q#, Yang Y#, Yan S, Liu J, Xu Z, Yu J, Song Y, Zhang A, Jin M*, A novel pro-inflammatory protein of Streptococcus suis 2 induces the Toll-like receptor 2-dependent expression of pro-inflammatory cytokines in RAW 264.7 macrophages via activation of ERK1/2 pathway, Front Microbiol. 2015, 6: 178.

6. Zhang Q, Liu J, Yan S, Yang Y, Zhang A, Jin M*, Fluoroquinolone-Resistant Haemophilus parasuis Isolates Exhibit More Putative Virulence Factors than Their Susceptible Counterparts, J Clin Microbiol. 2013, 51(9):3130.

7. Zhang Q, Zhou M, Song D, Zhao J, Zhang A, Jin M*, Molecular characterisation of resistance to fluoroquinolones in Haemophilus parasuis isolated from China, Int J Antimicrob Ag, 2013, 42:87–89.

8. Zhou M#, Zhang Q#, Zhao J, Jin M*, Haemophilus parasuis Encodes Two Functional Cytolethal Distending Toxins: CdtC Contains an Atypical Cholesterol Recognition/Interaction Region, PLoS ONE, 2012, 7(3): e32580. (共同第一作者)

9. Liu L, Zhang Q, Xu Z, Chen B, Zhang A, Sun X, Jin M*. Screening of Virulence-Related Transcriptional Regulators in Streptococcus suis. Genes (Basel). 2020, 11(9): E972.

10. Li C, He X, Yang Y, Gong W, Huang K, Zhang Y, Yang Y, Sun X, Ren W, Zhang Q, Wu X*, Zou Z*, Jin M*. Rapid and visual detection of African swine fever virus antibody by using fluorescent immunochromatography test strip. Talanta. 2020, 219:121284.

11. Liu L, Zhang Q, Xu Z, Huang J, Zhu W, Zhang A, Sun X, Jin M*. HP1717 Contributes to Streptococcus suis Virulence by Inducing an Excessive Inflammatory Response and Influencing the Biosynthesis of the Capsule. Microorganisms, 2019, 7:11.

12. Zhu W, Cai C, Li J, Zhang Q, Huang J, Jin M*. Characterization of protective antigen CbpB as an adhesin and a plasminogen-binding protein of Erysipelothrix rhusiopathiae. Res Vet Sci. 2019, 124:352-356.

13. Xu Z, Chen B, Zhang Q, Liu L, Zhang A, Yang Y, Huang K, Yan S, Yu J, Sun X, Jin M*, Streptococcus suis 2 transcriptional regulator TstS stimulates cytokine production and bacteremia to promote streptococcal toxic shock-like syndrome, Front Microbiol, 2018, 9:1309.

14. Zhu W, Wu C, Kang C, Cai C, Wang Y, Li J, Zhang Q, Sun X, Jin M*. Evaluation of the protective efficacy of four newly identified surface proteins of Erysipelothrix rhusiopathiae. Vaccine. 2018, 36(52):8079-8083.

15. Zhu W, Zhang Q, Li J, Wei Y, Cai C, Liu L, Xu Z, Jin M*, Glyceraldehyde-3-phosphate dehydrogenase acts as ­an adhesin in­ Erysipelothrix rhusiopathiae adhesion to­ porcine endothelial cells and ­as a receptor in­recruitment of­ host?bronectin and ­plasminogen, Vet Res, 2017, 48:16.

16. Wang Y, Li J, Zhang A, Zhu W, Zhang Q, Xu Z, Yan S, Sun X, Chen H, Jin M*, iTRAQ-based quantitative proteomic analysis reveals potential virulence factors of Erysipelothrix rhusiopathiae, Journal of Proteomics, 2017, 160: 28–37.

17. Kang, C, Zhang Q, Zhu W, Cai C, Sun X, Jin M*, Transcription analysis of the responses of porcine heart to Erysipelothrix rhusiopathiae, PLoS ONE, 2017, 12(10): e0185548.

18. Fu L, Zhao J, Lin L, Zhang Q, Xu Z, Han L, Xie C, Zhou R, Jin M, Zhang A*, Characterization of IgA1 protease as a surface protective antigen of Streptococcus suis serotype2, Microbes and Infection, 2016, 1.14, (18): 285~289.

19. Huang K, Yuan Z, Liu J, Zhang Q, Xu Z, Yan S, Zhang A, Jin M*. Identification and characterisation a surface-associated arginine peptidase in Streptococcus suis serotype 2. Microbiol Res. 2015, 170:168-176.

20. Wang N, Zou W, Yang Y, Guo X, Hua Y, Zhang Q, Zhao Z, Jin M*. Complete Genome Sequence of an H10N5 Avian Influenza Virus Isolated from Pigs in Central China, Journal of Virology, 2012, 86(24), pp 13865-13866.

授權專利

1. 金梅林，趙建平，周明光，宋岱松，張強，張安定，石建，康超，徐高原，陳煥春，表達副豬嗜血杆菌表面抗原的豬霍亂沙門氏菌減毒疫苗，2015.10.28，中國，ZL201310039113.8

2. 金梅林，趙建平，周明光，宋岱松，張強，張安定，石建，康超，徐高原，陳煥春，一種副豬嗜血杆菌減毒沙門氏菌苗，2015.10.28，中國，ZL201310039080.7

3. 金梅林，趙建平，周明光，宋岱松，張強，張安定，石建，康超，徐高原，陳煥春，一種副豬嗜血杆菌-豬霍亂沙門氏菌二聯基因工程苗，2015.10.28，中國，ZL201310040712.1

主講課程

《傳染病學》、《實驗診斷學》

基金項目

1. 国家自然科学基金青年科学基金項目，31702253，豬鏈球菌表面蛋白ZnMc誘導過度炎症反應的分子機制研究，2018/1-2020/12。

2. 中國博士後科學基金面上項目一等資助，2015M580654，豬鏈球菌2型抑炎蛋白HP1914作用機制的研究，2015/11-2017/11。

3. 國家重點研發計劃，2016YFD0500801，家禽重大疫病診斷新技術研究， 2016/7-2020/12。

4. 國家重點研發計劃，2020YFC0845800，新型冠狀病毒感染不同進程與宿主的相互作用研究，2020/3-2021/6。

5. 湖北省新型肺炎應急科技攻關項目，2020FCA001，新型冠狀病毒快速檢測技術産品研發，2020/1-2020/12。

6. 湖北省技術創新專項重大項目，2019ABA089,非洲豬瘟防控關鍵技術研究與示範，2019/1-2021/12。