張敏  博士、教授、博士生導師

教育經曆

1998-2002 華中農業大學水産學院 淡水漁業 理學學士學位

2003-2008 中科院水生生物研究所 水生生物學 理學博士學位

科研與學術工作經曆

2015-至今 華中農業大學 生命科學技術學院 教授

2009-2015 加州大學戴維斯分校 獸醫學院 博士後

2008-2009 中科院水生生物研究所 蛋白質工程 助理研究員

研究方向

RNA結合蛋白在器官發育與癌症發生中作用與機制

代表性研究成果

發表論文

1.Zhang, M., Zhang, J., Yan, W. & Chen, X. p73 expression is regulated by ribosomal protein RPL26 through mRNA translation and protein stability. Oncotarget 7, 78255-78268, doi:10.18632/oncotarget.13126 (2016).

2.Zhang, M., Xu, E., Zhang, J. & Chen, X. PPM1D phosphatase, a target of p53 and RBM38 RNA-binding protein, inhibits p53 mRNA translation via dephosphorylation of RBM38. Oncogene 34, 5900-5911, doi:10.1038/onc.2015.31 (2015).

3.Zhang, M.,Zhang, J.,Chen, XL.,Cho, SJ.,Chen, XB. (2013) Glycogen synthase kinase 3 promotes p53 mRNA translation via phosphorylation of RNPC1. Genes & Development 27(20): 2246-2258.

4.Zhang, M., Zhang, C., Li, J., Hanna, M., Zhang, X., Dai, H. and Xiao, W. (2011) Inactivation of YAP1 enhances sensitivity of the yeast RNR3-lacZ genotoxicity testing system to a broad range of DNA-damaging agents. Tox. Sci. 120: 310-321.

5.Zhang, M., Hanna, M., Li, J., Butcher, S., Dai, H. and Xiao, W. (2010) Creation of a hyperpermeable yeast strain to genotoxic agents through combined inactivation of PDR and CWP genes. Tox. Sci. 113: 401-411.

6.Zhang, M., Liang, Y., Zhang, X., Xu, Y., Dai, H. and Xiao, W. (2008) Deletion of yeast CWP genes enhances cell permeability to genotoxic agents. Toxicol. Sci. 103: 68-76.

7. Zhang, J., Xu, EX., Cong, R., Yang,WS.,Zhang, M., Chen, MY., Cardiffd, R., Imaie D., Wisnerb, E., Chen XB. (2014) Mice deficient in Rbm38, a target of the p53 family, are susceptible to accelerated aging and spontaneous tumors. Proc Natl Acad Sci U S A 111(52): 18637-18642.

8. Jiang, Y. Q.,Zhang, M; Qian, Yingjuan; et al (2014) Rbm24, an RNA-binding Protein and a Target of p53, Regulates p21 Expression via mRNA Stability. Journal of Biological Chemistry 289(6): 3164-3175.

9. Xu, Enshun; Zhang, Jin;Zhang, Min; et al. (2014) RNA-Binding Protein RBM24 Regulates p63 Expression via mRNA Stability. Molecular Cancer Research 12(3): 359-369.

10.Cho, SJ.,Rossi, A.,Jung, YS.,Yan, WS.,Liu, G.,Zhang, J.,Zhang, M.,Chen, XB. (2013) Ninjurin1, a target of p53, regulates p53 expression and p53-dependent cell survival, senescence, and radiation-induced mortality. Proceedings of the National Academy of Sciences of the United States of America 110(23): 9362-9367.

11. Chen, X. L.,Zhang, J.,Zhang, M.,Liu, S.,Yan, WS.,Jung, JH.,Chen, XB. (2012) Serine 123 Phosphorylation Modulates p21 Protein Stability and Activity by Suppressing Ubiquitin-independent Proteasomal Degradation. Journal of Biological Chemistry 287(41): 34410-34418.

12. Dai, H.,Zhang, M., Zhang, C., Wei, T., Xu, Y., and Xiao, W. （2011）Developing sensitive assessment system for environmental chemical carcinogens detection Curr. Opin. Biotechnol. 22, Supplement 1, S71.

13. Wang, Y., Zhang, X., Xiao, N.Zhang, M., Dai, H. Selection of a novel single-chain variable fragment antibody specifically against a linear epitope of white spot syndrome virus. Sheng Wu Gong Cheng Xue Bao, 2008, 24(8): 1387-94.

14. 楊毅;張敏;袁麗;張曉華;戴和平;.抗對蝦白斑綜合症病毒單鏈抗體P1D3基因在畢赤酵母中的分泌表達,生物工程學報,2006,22(6):973-978

授權專利

1.戴和平,肖偉，張敏,張曉華, 可用于檢測環境致癌物的高通透性面包酵母及其制備方法20080813 中國 CN101240251A

2.戴和平,肖偉，張敏,張曉華, 一種超高通透性面包酵母及其制備方法 20110713 中國 CN200910272505.2

3.戴和平,肖偉，張超，張敏,張曉華,一種對氧化損傷高敏感性的面包酵母及其制備方法 20130619 中國CN102120968A

主講課程

《發育生物學》

研究生招生專業

發育生物學

聯系方式

電子郵箱：minzhang@mail.jinxiniu168.com